I just picked up a Radial Tonebone Hot British distortion box. Great tone except I get HORRIBLE radio interference coming through the amp when it's kicked on. Any suggestions on how to rectify this?

Try a Power Conditioner.

Wow, let me know how it sounds with your Orion guitar as I was considering one of those due to not being able to get a decent overdrive sound from mine with my existing pedals.
 
I'd be very interested in your view.
I'm looking for a tone somewhere between Santana, Scott Henderson and Frank Gambale. Not that I play like them but that tone is what I like.

You've probably already read this, and there's nothing new here, but here's what the manual says:
I am getting radio signals though my amplifier ? Poor quality cables and bad grounding are usually the cause. Check to make sure your amplifier is properly grounded with a 3-prong A/C cord and that the wall receptacle is standard 3-prong duplex and wired correctly. Make sure you are using high quality coaxial guitar cables with proper shielding. Radial Tonebone pedals are engineered and tested to ensure RF is eliminated as a source of noise.