Lately I've been playing full range through a single 18 (the 210 cab looks so sad sitting in the hallway all by itself) with the TI Jazz Flats, and the tone is *there* if you know what I mean.  I get a very believable Jamerson sound with the neck pu at 100% and filter at zero, with just a hint of bridge pickup with filter at 2 or 3-ish and middle position on the q-switch, using the SWR emulation on my bass pod pro.  Granted, I'm using a long scale (more fundamental), but you should be able to get similar results..
John