I've been a Frank Zappa fan for a long time, but I've only recently tried to actually play any of his guitar lines (and it has been an education).  I know there are more than a few fans of Zappa Plays Zappa here, and I especially love this version of Peaches in Regalia.  
 
http://www.youtube.com/watch?v=X0bvaIphxfI&feature=related